Preparation of magnetically responsive albumin nanospheres and in vitro drug release studies


Ak G. , Yilmaz H., Sanlier S. H.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.42, ss.18-26, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/21691401.2013.768627
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Sayfa Sayıları: ss.18-26

Özet

In this work, doxorubicin (DOX)-loaded magnetic albumin nanospheres were prepared using desolvation method in order to develop magnetically responsive nanocarrier system. Nanoparticles were characterized with zetasizer, SEM, AFM, XRD and magnetometer. In vitro DOX release was also investigated. It was found that nanoparticles had spherical shape with narrow size distributions and had magnetic responsiveness. In addition, slower drug release was observed with nanoparticulate system compared with free DOX. Moreover, the release rate should accelerate at target sites (cancer cells or tissue) where proteolytic enzymes are more abundant as known; therefore, magnetic albumin nanospheres can be effective potential DOX carrier with targeting ability.