Development of gemcitabine-adsorbed magnetic gelatin nanoparticles for targeted drug delivery in lung cancer


Sanlier S. H. , Yasa M., Cıhnıoglu A. O. , Abdulhayoglu M., Yılmaz H., Ak G.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.44, ss.943-949, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 44
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/21691401.2014.1001493
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Sayfa Sayıları: ss.943-949

Özet

Magnetic iron oxide nanoparticles (IONPs) were coated with gelatin type B by means of the two-step desolvation method. Drug loading by adsorption was studied under various conditions such as different temperature, contact time, pH, and initial gemcitabine concentration. Further, Langmuir isotherm curves were constracted and constants were calculated. According to the Langmuir isotherm, the Gibbs free energy of the adsorption process at 25 degrees C was - 4.74 kJ/mol. On the other hand, this value at 37 degrees C was - 7.86 kJ/mol. In vitro drug release was performed at pH levels of 5 and 7.4, with gemcitabine-loaded magnetic gelatin nanoparticles and free gemcitabine, and both the results were subsequently compared.