The Universal Declaration of Human Rights declares that every human being is born free and equal in dignity and rights. Lesbian, gay, bisexual, transgender, and intersexual (LGBTI) people are represent a population of which society is not aware and tries ardently to avoid. Some a day from the past, it has been abusing the fact of everyone is dignified and equal. The literature of in the sampling of this group indicates that the processes of birth, health, illness, life and, even death are not come through them equal and comfortable; hereby how they important to cannot be missed and under a high risk. This conflict has sharper bends and barriers in more traditional and conservative societies like Turkey. This review has been written to clarify current conceptions which recently touched from nurses in nationally, to address LGBTI's life difficulties with basic headings in consideration of the historical, philosophical and theoretical approaches that can develop empathy and cognition and to discuss professional suggestions in this concept.