This study was conducted to determine the effects of the different intercropping design of maize/soybean compared with sole cropping, in combination with Vitormone (biofertilizer; Azotobacter) during 2012 and 2013. There were four different intercropping desigis were used in the experiment: i) sole maize and soybean, ii)1 maize + 1 soybean in alternate rows, iii) I maize + 2 soybeans in alternate rows and iv) 1 maize + 2 soybeans in intra rows under control with the Vitormone application. The experiment was laid out in a randomized complete block design with two factors and three replications. The results showed that the seed/grain yields and the Leaf area index of sole soybean and sole maize outperformed the intercropping. The highest yields for both maize (8.0 t ha(-1)) and soybean (3.26 t ha(-1)) and land equivalent ratio (1.26) were recorded at 1 maize + 2 soybeans in alternate rows among the intercropping. The effect of Vitormone was significantly positive for all cropping system except I maize + 1 soybean in alternate rows. This suggests that 1 maize + 2 soybeans in alternate rows can intercrop and combine with the Vitormone. The intercropping of cereal/legume has the potential to improve the utilization of resources in monocropped lands.