Isotretinoin (13-cis-retinoic acid) associated atrial tachycardia


HASDEMIR C. , SAGGAN A., SEKURI C., ILDIZLI M., ULUCAN C., Ceylan C.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, cilt.28, ss.348-349, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1540-8159.2005.09365.x
  • Dergi Adı: PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
  • Sayfa Sayıları: ss.348-349

Özet

We describe a 16-year-old boy who presented with palpitations for 1 week while being on isotretinoin treatment for nodulocystic facial acne for 3 months. Twenty four-hour Holter monitoring showed frequent premature atrial beats and episodes of nonsustained atrial tachycardia. He never had any episodes of palpitations previously. His complaints almost disappeared within a week after stopping the treatment. He remained asymptomatic since the discontinuation of the drug. The temporal relationship between isotretinoin treatment and patient's symptoms in the presence of documented arrhythmia suggests a drug-related cause. As a result, clinicians should be aware of the possible arrhythmogenic effect of isotretinoin.