Carbamylated low-density lipoprotein induces monocyte adhesion to endothelial cells through intercellular adhesion molecule-1 and vascular cell adhesion molecule-1


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APOSTOLOV E. O. , SHAH S. V. , Ok E. , BASNAKIAN A. G.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol.27, no.4, pp.826-832, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1161/01.atv.0000258795.75121.8a
  • Title of Journal : ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
  • Page Numbers: pp.826-832

Abstract

Objective - Carbamylated low-density lipoprotein (LDL), the most abundant modified LDL isoform in human blood, has been recently implicated in causing the atherosclerosis-prone injuries to endothelial cells in vitro and atherosclerosis in humans. This study was aimed at testing the hypothesis that carbamylated LDL acts via inducing monocyte adhesion to endothelial cells and determining the adhesion molecules responsible for the recruitment of monocytes.