Carbamylated low-density lipoprotein induces monocyte adhesion to endothelial cells through intercellular adhesion molecule-1 and vascular cell adhesion molecule-1

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APOSTOLOV E. O. , SHAH S. V. , Ok E. , BASNAKIAN A. G.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, cilt.27, ss.826-832, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 27 Konu: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1161/01.atv.0000258795.75121.8a
  • Dergi Adı: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
  • Sayfa Sayısı: ss.826-832

Özet

Objective - Carbamylated low-density lipoprotein (LDL), the most abundant modified LDL isoform in human blood, has been recently implicated in causing the atherosclerosis-prone injuries to endothelial cells in vitro and atherosclerosis in humans. This study was aimed at testing the hypothesis that carbamylated LDL acts via inducing monocyte adhesion to endothelial cells and determining the adhesion molecules responsible for the recruitment of monocytes.