Synthesis and anticonvulsant activity of some alkanamide derivatives


TARIKOĞULLARI H. A. , KILIÇ F. S. , EROL K., PABUÇÇUOĞLU M. V.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.60, ss.593-598, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 60 Konu: 10
  • Basım Tarihi: 2010
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Sayfa Sayıları: ss.593-598

Özet

A group of N-phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at omega position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-y1)-N(2,6-dimethylphenyl)acetamide.