The diagnostic value of multimodal evoked potentials in the determination of subclinical neurological involvement of Wilson's disease


ECEVIT C., OZGENC F., GÖKÇAY F. , ÇELEBİSOY N. , BARAN M., YAGCI R. V.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.24, no.6, pp.627-632, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1097/meg.0b013e3283526f81
  • Title of Journal : EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Page Numbers: pp.627-632

Abstract

Aims Wilson's disease (WD) is a progressive degeneration of hepatolenticular tissue caused by excessive tissue-damaging copper accumulation and in which liver involvement most frequently presents in childhood. Neurological signs also accompany liver disease with time. However, subclinical neurological involvement may occur earlier and diagnostic methods that reveal this subclinical involvement are not well established. The aim of the current study is to assess the subclinical neurological involvement by using multimodality evoked potential (EP) measurements and to explore the relationship between neurological disease and the severity of liver damage.