Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis


PIRHAN D., Atilla G. , EMINGIL G. , SORSA T., TERVAHARTIALA T., BERDELİ A.

JOURNAL OF CLINICAL PERIODONTOLOGY, vol.35, no.10, pp.862-870, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 10
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1600-051x.2008.01302.x
  • Title of Journal : JOURNAL OF CLINICAL PERIODONTOLOGY
  • Page Numbers: pp.862-870
  • Keywords: GCF, gene polymorphism, MMP-1, periodontal therapy, periodontitis, GINGIVAL CREVICULAR FLUID, MATRIX METALLOPROTEINASE-1 PROMOTER, SINGLE NUCLEOTIDE POLYMORPHISM, TISSUE INHIBITOR, RISK-FACTORS, GENE, SUSCEPTIBILITY, MECHANISMS, IDENTIFICATION, PATHOGENESIS

Abstract

Aims: The aims of this study were to investigate (1) the matrix metalloproteinase-1 (MMP-1) promoter polymorphisms in severe chronic periodontitis (CP), (2) the relationship of periodontal therapy outcome with these genotypes, and (3) the gingival crevicular fluid (GCF) MMP-1 levels-MMP-1 genotype correlation.