Gingival tissue proteoglycan and chondroitin-4-sulphate levels in cyclosporin A-induced gingival overgrowth and the effects of initial periodontal treatment


VARDAR S., BAYLAS H., ZIHNIOGLU F. , Buduneli N. G. , Emingil G. , Atilla G.

JOURNAL OF CLINICAL PERIODONTOLOGY, vol.32, no.6, pp.634-639, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1600-051x.2005.00724.x
  • Title of Journal : JOURNAL OF CLINICAL PERIODONTOLOGY
  • Page Numbers: pp.634-639

Abstract

Objectives: Cyclosporin A (CsA) is a potent immunosuppressive drug used in organ transplant patients to prevent graft rejection. CsA-induced gingival overgrowth is one of the side effects of this drug and its pathogenesis is still unclear. The present study was planned to comparatively analyse total proteoglycan (PG) and chondroitin-4-sulphate (C4S) levels in CsA-induced overgrown gingival tissue samples obtained before and after initial periodontal treatment and to compare these findings with the situation in healthy gingiva.