Gingival tissue proteoglycan and chondroitin-4-sulphate levels in cyclosporin A-induced gingival overgrowth and the effects of initial periodontal treatment


VARDAR S., BAYLAS H., ZIHNIOGLU F. , Buduneli N. G. , Emingil G. , Atilla G.

JOURNAL OF CLINICAL PERIODONTOLOGY, cilt.32, ss.634-639, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1600-051x.2005.00724.x
  • Dergi Adı: JOURNAL OF CLINICAL PERIODONTOLOGY
  • Sayfa Sayıları: ss.634-639

Özet

Objectives: Cyclosporin A (CsA) is a potent immunosuppressive drug used in organ transplant patients to prevent graft rejection. CsA-induced gingival overgrowth is one of the side effects of this drug and its pathogenesis is still unclear. The present study was planned to comparatively analyse total proteoglycan (PG) and chondroitin-4-sulphate (C4S) levels in CsA-induced overgrown gingival tissue samples obtained before and after initial periodontal treatment and to compare these findings with the situation in healthy gingiva.