Allopurinol hypersensitivity syndrome as a cause of hepatic centrilobular hemorrhagic necrosis


Mete N. , Yilmaz F. , Gulbahar O. , Aydin A. , Sin A. Z. , Kokuludag A. , ...Daha Fazla

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, cilt.13, ss.281-283, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 13 Konu: 4
  • Basım Tarihi: 2003
  • Dergi Adı: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
  • Sayfa Sayıları: ss.281-283

Özet

Extensive and severe hepatic centrilobular hemorrhagic necrosis is a common finding in hepatic vein obstruction and Budd-Chiari syndrome. Some drugs, including allopurinol, can also cause this histopathologic appearance but to our knowledge in this setting the lesions are not so massive. Here we report a case of a 41-year-old female who developed fever, pruritic skin rash, jaundice, eosinophilia, abnormal liver function tests, and acute renal failure 3 weeks after the beginning of allopurinol treatment, complicated with severe hepatocyte necrosis around most terminal hepatic venules suggesting Budd-Chiari syndrome.