Tc-99m-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats


ERTAY T., Unak P. , ÖZDOĞAN O., Biber F. Z. , Zihnioglu F. , Medine E. I. , ...More

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.269, no.1, pp.21-28, 2006 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 269 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1007/s10967-006-0226-2
  • Title of Journal : JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Page Numbers: pp.21-28

Abstract

A glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7 +/- 0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with Tc-99m-GH-exorphin C glucuronide (Tc-99m-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that Tc-99m-GEG can be used as a vehicle to target tumors.