Intraoperative extracorporeal irradiation and re-implantation of involved bone for the treatment of musculoskeletal tumors


ANACAK Y. , SABAH D. , DEMİRCİ S., KAMER S.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, cilt.26, ss.571-574, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 26 Konu: 4
  • Basım Tarihi: 2007
  • Dergi Adı: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • Sayfa Sayısı: ss.571-574

Özet

The purpose of this trial is to evaluate the results of musculoskeletal tumors which is treated with limb salvage surgery and extracorporeal radiotherapy. Patients were treated with en-bloc resection followed by 50 Gy single dose extracorporeal irradiation and re-implantation of involved bone segments. Nine of fifteen were female and 6 were male, median age was 19. Tumor originated from tibia in 7 patients, femur in 3, humerus in 3, calcaneus in I and scapula in 1. Preoperative chemotherapy was given to 12 patients, 3 of them had not been treated previously. Median follow-up time of the survivors was 22 months (range 2-47 months); local recurrence and lung metastases occurred in one patient (local recurrence was away from the re-implanted bone segment), and lung metastases were reported in another 3 patients. Wound healing problems occurred in 4 patients and delayed union in 2 patients. Amputation was performed in 2 patients due to uncontrolled infection, and infected bone was replaced by a fibula graft in another patient. Treatment was successful in 12 patients where functional results were good in 9, excellent in 2 and not evaluated in 1.