In vitro studies on controlled-release cellulose acetate films for local delivery of chlorhexidine, indomethacin, and meloxicam

Cetin E. Ö. , Buduneli N. G. , Atlihan E., Kirilmaz L.

JOURNAL OF CLINICAL PERIODONTOLOGY, cilt.31, ss.1117-1121, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 31 Konu: 12
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1600-051x.2004.00620.x
  • Sayfa Sayıları: ss.1117-1121


Background: Delivery of medications into periodontal pockets to suppress or eradicate the pathogenic microbiota or modulate the inflammatory response, thereby limiting periodontal tissue destruction, has attracted significant interest with the purpose of effective periodontal treatment. However, no study has previously attempted to develop a controlled-release formulation of anti-inflammatory agents to be used in the field of periodontology. The aim of the present study was to examine the in vitro release profile of chlorhexidine gluconate, indomethacin, and meloxicam from cellulose acetate films.