STUDY ON LABELING CONDITIONS OF I-125 SYNKAVIT BY THE IODOGEN METHOD


ÖZDEMİR D., UNAK P.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-LETTERS, cilt.187, ss.277-283, 1994 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 187 Konu: 4
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1007/bf02166555
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-LETTERS
  • Sayfa Sayısı: ss.277-283

Özet

Labeling conditions of synkavit (2-methyl-1,4-naphthoquinol disodium phosphate) with iodine-125 have been studied. In this study, labeling temperature, reaction time, successive using of iodogen coated tubes, iodogen amount and synkavit concentrations have been determined to get optimum conditions for maximum labeling. Final results showed that when the labeling temperature, reaction time, synkavit concentration, and iodogen amount were, at room temperature, 15 min (in the case of successive using of three iodogen coated tubes), 2 mg ml-1 and 5 mg, respectively; labeling yield was 90% and specific activities of the order of 555 GBq mmol-1 (15 Ci mmol-1) have been obtained.