Evaluation of MIF-173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

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Gurel C. , Inanir A., Nural A. F. , Tekcan A., Rustemoglu A., Yigit S.

BALKAN MEDICAL JOURNAL, vol.33, pp.614-619, 2016 (Journal Indexed in SCI)

• Publication Type: Article / Article
• Volume: 33
• Publication Date: 2016
• Doi Number: 10.5152/balkanmedj.2016.141103
• Title of Journal : BALKAN MEDICAL JOURNAL
• Page Numbers: pp.614-619
• Keywords: Ankylosing spondylitis, macrophage migration inhibitory factor, polymorphism, MIGRATION INHIBITORY FACTOR, JUVENILE IDIOPATHIC ARTHRITIS, INFLAMMATORY-BOWEL-DISEASE, FACTOR GENE POLYMORPHISMS, RHEUMATOID-ARTHRITIS, ASSOCIATION, MIF, SUSCEPTIBILITY, POPULATION, ONSET

Abstract

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play a role in the progression of several inflammatory disorders.