New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Shirinzadeh, Hanif; Neuhaus, Eddy; Erguc, Elif; Aliyev, Alev; Gürer Orhan, HANDE; Süzen, Sibel

doi:10.1016/j.bioorg.2020.104219

New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Shirinzadeh H., Neuhaus E., Erguc E. I. , Aliyev A. T. , Gürer Orhan H. , Süzen S.

BIOORGANIC CHEMISTRY, vol.104, 2020 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 104
Publication Date: 2020
Doi Number: 10.1016/j.bioorg.2020.104219
Title of Journal : BIOORGANIC CHEMISTRY
Keywords: Indole, Melatonin, Synthesis, Antioxidant activity, Cytotoxicity, CYP1 inhibition, IN-VITRO ANTIOXIDANT, INDOLE-BASED ANALOGS, HYDRAZONE DERIVATIVES, SCAVENGING ACTIVITY, OXIDATIVE STRESS, DESIGN, ASSAYS, BEHAVIOR

Abstract

Over the last decade, there has been substantial interest in the use of melatonin (MLT) and MLT-like compounds in the treatment of several diseases. MLT can scavenge different reactive oxygen species and can also stimulate the synthesis of antioxidant enzymes.