Discovery of new Toxoplasma gondii antigenic proteins using a high throughput protein microarray approach screening sera of murine model infected orally with oocysts and tissue cysts


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Döşkaya M. , Liang L., Jain A., Can H. , Iz S. , Felgner P. L. , ...More

PARASITES & VECTORS, vol.11, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2018
  • Doi Number: 10.1186/s13071-018-2934-1
  • Title of Journal : PARASITES & VECTORS
  • Keywords: Toxoplasma gondii, Oocysts, Sporozoite, Tissue cyst, Bradyzoite, Protein microarray, Antigen discovery, Vaccine, Diagnostics, PROTECTIVE IMMUNE-RESPONSES, OCULAR TOXOPLASMOSIS, RECOMBINANT ANTIGENS, DNA VACCINATION, IMMUNIZATION, OUTBREAK, MICE, GRA7, INDUCTION, AVIDITY

Abstract

Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that causes congenital toxoplasmosis, as well as other serious clinical presentations in immune compromised humans. The parasite has also been recently linked to behavioral diseases in humans and other mammalian hosts. New antigens are being evaluated to develop a diagnostic kit for the diagnosis of acute infection or a protective vaccine.