ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.20, ss.2316-2323, 2020 (SCI İndekslerine Giren Dergi)
Background: Ruxolitinib is a selective JAK1/2 inhibitor approved by the FDA for myelofibrosis in 2014 and nowadays, comprehensive investigations on the potential of the agent as a targeted therapy for haematological malignancies are on the rise. In multiple myeloma which is a cancer of plasma cells, the Interleukin-6/JAK/STAT pathway is emerging as a therapeutic target since the overactivation of the pathway is associated with poor prognosis.