This study focused on the earthquake network properties of Southern California. The event synchronization method was used to create an earthquake network of the aforementioned region. Local network measurements were utilized to investigate the most active and prominent subregions and their effects on the earthquake dynamics of the region. These measurements showed that two regions (the Eastern California Shear Zone (ECSZ) and the region that begins at the South end of the San Andreas Fault Zone, continues through the San Jacinto and Elsinore Faults, and terminates at the Lugano Salada Fault) dominate the earthquake dynamics of Southern California. Both regions are seismologically active and exhibit spatial continuity from the network perspective. Additionally, many cells in these regions serve as bridges for stress transfers. It appears that not only are few of these cells responsible for the earthquake dynamics at the ECSZ but also nearly the entire ECSZ region plays an important role in earthquake activity. The Garlock Fault Zone, a small region near Los Angeles, and a small region along the San Diego Trough Fault had no large earthquake during the analyzed time region, but these measurements show their potential for future activity.