Toxoplasma gondii RH Ankara: Production of evolving tachyzoites using a novel cell culture method

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Değirmenci A. , Döşkaya M. , Caner A. , Çiçek C. , Korkmaz M. , Guruz Y. , ...Daha Fazla

EXPERIMENTAL PARASITOLOGY, cilt.128, ss.1-8, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 128
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.exppara.2011.01.019
  • Sayfa Sayıları: ss.1-8


Toxoplasma gondii is one of the most researched parasite due to its easy growth both in vitro and in vivo. Tachyzoites, derived from mouse or rat peritoneum encounters ethical and economical problems when used for research or diagnostic purposes. Currently, research has focused on determining the most suitable cell culture environment to reach highest amount of viable tachyzoites with least host cell contamination. However, gene expression changes that take place throughout the adaptation of evolving T. gondii strains to continuous cell cultures appear as a problem.