Biological affinity evaluation of Lawsonia inermis origin Lawsone compound and its radioiodinated form via in vitro methods


TEKİN V., Muftuler F. Z. B. , Guldu O. K. , Kilcar A. Y. , MEDİNE E. İ. , YAVUZ M., ...Daha Fazla

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.303, ss.701-708, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 303 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10967-014-3435-0
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.701-708

Özet

WST-1-based cytotoxicity assay of lawsone (LW) was performed on MCF7, Caco2, BJ and Keratinocyte cells and viabilities were found as over 90 % for all cells. Significant wound healing effect of LW was reported on Keratinocyte cells. Antibacterial and antifungal activities of LW were tested on seven microorganisms with three concentrations and 1,000 A mu g/disc of LW showed antibacterial effect on Bacillus subtilis. In vitro cell incorporation of radioiodinated LW (I-131-LW) was evaluated on same cells. Keratinocyte cells uptake were 5 times more. Consequently, I-131-LW was found usable for researches about especially skin diseases in addition to breast and intestinal cancer.