Synthesis of novel Schiff base ligands from gluco- and galactochloraloses for the Cu(II) catalyzed asymmetric Henry reaction


ALKAN S., TELLİ F. , SALMAN Y. , ASTLEY S. T.

CARBOHYDRATE RESEARCH, vol.407, pp.97-103, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 407
  • Publication Date: 2015
  • Doi Number: 10.1016/j.carres.2015.01.023
  • Title of Journal : CARBOHYDRATE RESEARCH
  • Page Numbers: pp.97-103

Abstract

A series of chiral Schiff base ligands has been prepared using aminochloralose derivatives of glucose and galactose. These ligands were used as catalysts in the asymmetric Henry reaction in the presence of Cu(II) ions giving yields of up to 95%. An interesting solvent dependency on enantiomeric control was observed with the best enantiomeric excesses (up to 91%) being obtained in the presence of water. (C) 2015 Elsevier Ltd. All rights reserved.