The Role of Body Mass Index in Triple Negative Breast Cancer.

Cakar B. , MUSLU U., ERDOĞAN A. , OZISIK M., OZISIK H. , DALGIC C. , ...More

Oncology research and treatment, vol.38, no.10, pp.518-22, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.1159/000439551
  • Title of Journal : Oncology research and treatment
  • Page Numbers: pp.518-22
  • Keywords: Breast cancer, Triple negative, Body mass index, Obesity, POOLED ANALYSIS, OBESITY, SURVIVAL, WOMEN, RISK, EXPERIENCE, OUTCOMES, DISEASE, WEIGHT, IMPACT


Background: Triple-negative breast cancer (TNBC) has none of the targeted treatment choices due to its distinct biological property, making this subtype a unique disease. In this study, we evaluated the impact of obesity on clinical outcomes of TNBC. Methods: The data of breast cancer patients admitted to our department were collected. TNBC was defined as lack of estrogen receptor (ER), progesterone receptor (PR) and HER-2. The body mass index (BMI) of 112 TNBC patients was calculated with weight at the time of diagnosis and height. The patients were classified into groups with a BMI of < 25 (normal/underweight), 25-29.9 (overweight) or >= 30 (obese). After a mean follow-up of 23.2 +/- 15.5 months, there were 12 recurrences (10.71%) and 6 deaths (5.35%). Disease-free survival (DFS) and overall survival (OS) were assessed. Results: The survival analyses of all the patients did not demonstrate any differences in OS or DFS in obese as compared to non-obese patients. However, we showed that obesity was associated with a poorer OS for postmenopausal TNBC patients (p < 0.05). Conclusion: Obesity is related to a poorer OS in postmenopausal TNBC patients. Due to the heterogeneous disease profile of TNBC, larger randomized studies will be needed to clarify the exact role of obesity in TNBC. (C) 2015 S. Karger GmbH, Freiburg