Iridium(I)-Catalyzed Alkylation Reactions To Form alpha-Alkylated Ketones

GENC S., GÜNNAZ S. , CETINKAYA B., GÜLCEMAL S. , GÜLCEMAL D.

JOURNAL OF ORGANIC CHEMISTRY, cilt.83, ss.2875-2881, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 83 Konu: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1021/acs.joc.8b00043
  • Dergi Adı: JOURNAL OF ORGANIC CHEMISTRY
  • Sayfa Sayıları: ss.2875-2881

Özet

A highly effective and green procedure for the formation of alpha-alkylated ketones has been disclosed via the reaction of primary alcohols with secondary alcohols and ketones by using [IrCl(COD)(NHC)] complexes as a catalyst. Various alpha-alkylated ketones were obtained in high yields from the alkylation of alcohol with alcohol and ketone with alcohol through a borrowing hydrogen reaction by using 0.05-0.5 mol % iridium(I) and a catalytic amount of KOH (5-10 mol %) as the base under air atmosphere and within very short reaction times.