Iridium(I)-Catalyzed Alkylation Reactions To Form alpha-Alkylated Ketones

GENC S., GÜNNAZ S. , CETINKAYA B., GÜLCEMAL S. , GÜLCEMAL D.

JOURNAL OF ORGANIC CHEMISTRY, vol.83, no.5, pp.2875-2881, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1021/acs.joc.8b00043
  • Title of Journal : JOURNAL OF ORGANIC CHEMISTRY
  • Page Numbers: pp.2875-2881

Abstract

A highly effective and green procedure for the formation of alpha-alkylated ketones has been disclosed via the reaction of primary alcohols with secondary alcohols and ketones by using [IrCl(COD)(NHC)] complexes as a catalyst. Various alpha-alkylated ketones were obtained in high yields from the alkylation of alcohol with alcohol and ketone with alcohol through a borrowing hydrogen reaction by using 0.05-0.5 mol % iridium(I) and a catalytic amount of KOH (5-10 mol %) as the base under air atmosphere and within very short reaction times.