Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents


TEKGÜL H. , Saz U. , Polat M., Tekgul N., KÖSE T.

NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY, vol.38, no.2, pp.90-96, 2021 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.4103/nsn.nsn_94_20
  • Title of Journal : NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
  • Page Numbers: pp.90-96

Abstract

Context: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to healthy developing children and adolescents. Settings and Design: In this cross-sectional study, we measured TMS evoked parameters associated with cortical and spinal stimulation obtained from the four extremities of 46 healthy children and adolescents (21 boys and 25 girls; mean +/- standard deviation age: 6.4 +/- 1.2 years; range: 3.0-20.5 years). Statistical Analysis: Spearman's correlation coefficients were calculated for each variable (weight and height) as a function of motor evoked potential (MEP) response latency and central motor conduction time (CMCT). Pearson's Chi-square test was used to determine the inter-variable correlations. Results: Latencies of MEPs were correlated with age (P < 0.001, r = 0.6948) and height (P < 0.006, r = 0.7994). Amplitudes of active-state MEPs were significantly higher than those of resting-state MEPs associated with the upper and lower extremities. The mean values for active-state MEP latencies were lower than those for resting-state MEPs. The CMCT and magnitudes of latency jumps were calculated using reliable MEP data for children and adolescents. Additionally, the unresponsiveness rates were significantly higher for children aged below 7 years. Conclusion: The TMS evoked parameters investigated in this study are necessary to accurately assess corticospinal pathway development in healthy children and adolescents.