Amyloidosis is a disorder characterized by accumulation of B sheet misfolded proteinosis, amorph material at extracellular matrix. Amyloidosis is a serious disease that can cause mortality and severe morbidity with organ involvement especially kidney, heart, nerve, and spleen. Amyloidosis must be kept in mind particularly when multiorgan involvement occurs. In our case 1.5 months later after thyroid operation, our patient admitted with oedema, creatinine, blood urea nitrogen elevation and massive proteinurea. We suspected nephrotic syndrome and in his past thyroidectomy specimen reexamination amyloid aggregation was detected. It is an interesting case because of AA secondary type of amyloidosis involvement in thyroid tissue is rare and being diagnosed from past thyroidectomy specimen staining instead of making new organ tissue biopsies.