TCuOX-GO (TCuO: Tomato skin inspired copper oxide; GO: Graphene oxide; X, weight percentage of cop-per oxide: 10, 50, and 90) catalysts were prepared and their performances on acetaminophen removal were tested in catalytic wet air oxidation (CWAO) process. Copper oxide particles were synthesized from tomato skin biotemplates to contribute valorization of food wastes and the development of ecofriendly catalysts. The most effective catalyst was determined as TCuO50-GO. Under the optimum conditions 52.1% TOC removal and 96.2% acetaminophen degradation efficiencies were achieved. The acetamino-phen degradation kinetics was found to fit Langmuir-Hinshelwood model. The heat of adsorption and adsorption entropy were calculated as-19148.8 J/mol (for oxygen),-10380.9 J/mol (for acetaminophen),-10.17 J/molK (for oxygen), and-14.5 J/molK (for acetaminophen), respectively. The use of biomimetic catalysts in CWAO process and investigation of treatment cost and reaction kinetics in the presence of the biomimetic catalysts are the main original approaches of this study.