Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes


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Karadeniz H. , Erdem Gürsan K. A.

Marmara Pharmaceutical Journal, cilt.23, ss.682-688, 2019 (Hakemli Üniversite Dergisi)

  • Cilt numarası: 23 Konu: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.12991/jrp.2019.176
  • Dergi Adı: Marmara Pharmaceutical Journal
  • Sayfa Sayıları: ss.682-688

Özet

The interaction of lumazine (LMZ) with dsDNA was investigated with differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) by using disposable carbon nanotubes-modified pencil graphite electrode (CNTs-PGE). The passive adsorption process was used to modify the electrode surface by CNTs and then dsDNA was immobilized onto the modified PGEs. The performance of CNT-PGEs was studied by examining the optimum analytical conditions with DPV and then impedance method was performed to characterize the modification of CNTs onto the electrode surface.