Electrochemical detection of anticancer drug lumazine and DNA interaction by using carbon nanotube modified electrodes

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Karadeniz H. , Erdem Gürsan K. A.

Marmara Pharmaceutical Journal, vol.23, no.4, pp.682-688, 2019 (National Refreed University Journal)

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.12991/jrp.2019.176
  • Title of Journal : Marmara Pharmaceutical Journal
  • Page Numbers: pp.682-688


The interaction of lumazine (LMZ) with dsDNA was investigated with differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) by using disposable carbon nanotubes-modified pencil graphite electrode (CNTs-PGE). The passive adsorption process was used to modify the electrode surface by CNTs and then dsDNA was immobilized onto the modified PGEs. The performance of CNT-PGEs was studied by examining the optimum analytical conditions with DPV and then impedance method was performed to characterize the modification of CNTs onto the electrode surface.