Granulocyte colony-stimulating factor provides protection against cardiovascular autonomic neuropathy in streptozotocin-induced diabetes in rats


Erbas O., Solmaz V., TAŞKIRAN D.

DIABETES RESEARCH AND CLINICAL PRACTICE, vol.107, no.3, pp.377-383, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1016/j.diabres.2014.12.018
  • Title of Journal : DIABETES RESEARCH AND CLINICAL PRACTICE
  • Page Numbers: pp.377-383

Abstract

Aims: Cardiovascular autonomic neuropathy (CAN) is a relatively common and detrimental complication of diabetes mellitus (DM). Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP), are thought to play significant roles in diabetes-related cardiovascular disease. Accumulating evidence indicates the neuroprotective effects of granulocyte-colony stimulating factor (G-CSF) in different neurological disorders. The purpose of the study is to investigate the role of CGRP and VIP and possible effects of G-CSF on CAN in type I DM model in rats.