Effects of Preoperative Gabapentin on Postoperative Pain after Radical Retropubic Prostatectomy


Creative Commons License

DENİZ M. N. , SERTÖZ N. , ERHAN E. , UGUR G.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.40, no.6, pp.2362-2369, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1177/030006051204000635
  • Title of Journal : JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Page Numbers: pp.2362-2369

Abstract

OBJECTIVE: The impact of preoperative gabapentin on tramadol consumption using patient-controlled analgesia (PCA) and postoperative pain was assessed in patients undergoing radical retropubic prostatectomy (RRP). METHODS: In this prospective, randomized trial, 51 patients undergoing RRP were randomized into two groups: the gabapentin group received 900 mg gabapentin orally 2 h before surgery; the control group did not receive gabapentin. Postoperative analgesia was provided by tramadol PCA. Pain was assessed using a visual analogue scale for, 24 h, postoperatively. RESULTS: Mean cumulative tramadol consumption at 24 h was comparable in the two groups. Pain scores at 45 min, 60 min and 2 h postoperatively, and the number of patients who required rescue analgesia, were significantly lower in the gabapentin group than in the control group. Side-effects were similar in the two groups. CONCLUSIONS: Preoperative administration of 900 mg gabapentin did not decrease tramadol consumption, but was associated with lower pain scores in the early postoperative phase and a reduced need for rescue analgesia, compared with controls, in patients undergoing RRP.