Investigation of the synergistic effects of paclitaxel and herbal substances and endemic plant extracts on cell cycle and apoptosis signal pathways in prostate cancer cell lines

Doğan Ş., Balci O., Biray A. , Yilmaz S. , Kayabaşi Ç., Turna B., ...More

GENE, vol.687, pp.261-271, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 687
  • Publication Date: 2019
  • Doi Number: 10.1016/j.gene.2018.11.049
  • Title of Journal : GENE
  • Page Numbers: pp.261-271
  • Keywords: Paclitaxel, Herbal substances, Endemic plant extracts', Prostate cancer cell lines, Cell cycle, Apoptosis, GROWTH, INHIBITION, INDUCTION, ENZYME


Paclitaxel, which isolated from Taxes brevifolia, is recently started to be used against prostate cancer treatment and it is a very effective compound against cancer. In this study, we aimed to test the synergistic effect of two plant active compounds (sulphoraphane (SFN) and silymarin (SILY)) and several endemic plant species from Turkey (such as Phlomis leucophracta, Rubia davisiana, Alkanna tinctoria), which are known to have antic-arcinogenic effect on androgen-independent PC3 and DU145, and androgen-dependent VCaP prostate cancer cell lines, with paclitaxel on the expression of cell cycle signaling and apoptosis regulator genes.