Immunohistochemical and Histopathological Evaluation of 2,4-Dichlorophenoxyacetic Acid-Induced Changes in Rat Kidney Cortex


UYANIKGİL Y. , ATES U., BAKA M. , Bicer S., OZTAS E., Ergen G.

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, cilt.82, ss.749-755, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 82 Konu: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00128-009-9689-5
  • Dergi Adı: BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • Sayfa Sayıları: ss.749-755

Özet

This study aims to investigate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on rat kidney cortex histology. Oral exposure of rats to 2,4-D for 28 days resulted in decreases in body weight gain and kidney weight. Histological examination showed degeneration in renal corpuscles and podocytes; vacuolization in the glomerulus with disintegration of the basal membrane; tissue edema; vacuolization, cystic dilation and invagination of the basal laminae in the tubular structures; dilation and congestion in renal corpuscular vessels and marked decrease in glomerular and stromal fibronectin reaction; suggesting that subacute 2,4-D administration induces dose-dependent histopathological degenerative effects in rat kidney cortex.