Association between bronchopulmonary dysplasia and MBL2 and IL1-RN polymorphisms


Cakmak B. C. , Calkavur S., Ozkinay F., Koroglu Ö. , ONAY H. , Itirli G., ...Daha Fazla

PEDIATRICS INTERNATIONAL, cilt.54, ss.863-868, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 54 Konu: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1111/j.1442-200x.2012.03714.x
  • Dergi Adı: PEDIATRICS INTERNATIONAL
  • Sayfa Sayıları: ss.863-868

Özet

Background: The imbalance between pro-inflammatory and anti-inflammatory cytokines may play a role in the development of bronchopulmonary dysplasia (BPD) in preterm infants. Mannose binding lectin (MBL) codon 54 and interleukin 1 receptor antagonist gene (IL1-RN) polymorphisms cause genetic predisposition to increased risk of infection and inflammation, therefore may increase the risk of BPD. The aim of this study was to investigate the relationship between MBL, IL1-RN gene polymorphisms and BPD development in preterm infants.