Genetic factors associated with the predisposition to late onset Alzheimer's disease


DURMAZ A. , Kumral E., Durmaz B. , ONAY H. , Aslan G. I. , Ozkinay F. F. , ...Daha Fazla

GENE, cilt.707, ss.212-215, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background Alzheimer's disease is a progressive, irreversible neurodegenerative disorder characterized by loss of memory and cognitive skills. More than 90% of cases are sporadic and have later age of onset. Many studies have shown a genetic predisposition for late onset Alzheimer's disease (LOAD). The most studied genetic predisposition factor is apolipoprotein E gene besides other susceptibility genes involved in vascular pathologies, homocysteine metabolism, and neuronal growth and differentiation such as methylenetetrahydrofolate reductase (MTHFR), angiotensin-converting enzyme (ACE), APOB and brain derived neurotrophic factor (BDNF).