HIPPEASTRINE SYNTHESIS - A COMBINED BIO-DIOXYGENATION ORGANOIRON CHIRALITY RELAY APPROACH


ASTLEY S. T. , MEYER M., STEPHENSON G.

TETRAHEDRON LETTERS, cilt.34, ss.2035-2038, 1993 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 34 Konu: 13
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/s0040-4039(00)60339-8
  • Dergi Adı: TETRAHEDRON LETTERS
  • Sayfa Sayısı: ss.2035-2038

Özet

The regio- and enantioselective preparation of tricarbonyl(eta5-6(S)-endo-methoxy-1(S)-ethoxycyclohexadienyl)iron(1+) hexafluorophosphate(1-) (3, R = OEt), via a biotransformation entry, is described. The optical purity of 3 (R = OEt), which is required as an intermediate for hippeastrine synthesis, was found to be > 98% e.e. by an NMR chiral shift method.