Encapsulation of insulin in chitosan-coated alginate beads: Oral therapeutic peptide delivery


Onal S. , Zıhnıoglu F.

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY, cilt.30, ss.229-237, 2002 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 30
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1081/bio-120004343
  • Dergi Adı: ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY
  • Sayfa Sayıları: ss.229-237

Özet

Insulin was encapsulated in calcium alginate beads coated with chitosan. Its release from alginate-chitosan and alginate-chitosan-glutaraldehyde beads was studied in artificial gastric (pH 1.2) and intestinal (pH 7.5) fluids. By comparing the release amounts, the ionic interaction between alginate-chitosan matrix with the medium pH's, intestinal fluid was found to be the better. The degradation of released insulin was also searched, even after 6 h incubation, the beads remained stable and the undegraded insulin seemed to be sufficient for the physiological conditions. Consequently, it can be said that the system can be offered for oral delivery of the therapeutic peptide drug insulin.