Photoinactivation with Novel Porphyrin Derivatives: An in Vitro Study on Multi-drug Resistant Escherichia coli

Akbiyik A., TAŞLI H. , Topaloglu N., ALPTÜZÜN V. , Parlar S.

Medical Technologies National Congress (TIPTEKNO), Trabzon, Türkiye, 12 - 14 Ekim 2017 identifier identifier


In the study, it was aimed to investigate the bactericidal activity of antimicrobial photodynamic therapy (aPDT) performed on in-vitro conditions with novel cationic-porphyrin derivatives (CPDs) on multidrug resistant E. coli. In aPDT experiments performed with different concentrations of photosensitizer and different energy densities, 99.9999% or more decrease in bacterial survival was detected. aPDT carried out with CPDs at concentrations below the MIC values has the potential to display a strong antimicrobial activity against the MDR E. coli clinical isolates.