Leflunomide Is a New Oral Agent in Treatment of Acute Pancreatitis?


Kutluana U., ORUÇ N. , NART D. , Kaptanoglu B., Yonetci N., OZUTEMIZ O.

PANCREAS, cilt.39, ss.237-242, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 39 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/mpa.0b013e3181bab6a9
  • Dergi Adı: PANCREAS
  • Sayfa Sayıları: ss.237-242

Özet

Objectives: Nuclear factor-kappa B (NF-kappa B) is a potent mediator in several steps of acute pancreatitis. Leflunomide is a novel immunomodulating drug that is also a potent inhibitor of NF-kappa B activation. The aim of this study was to investigate the effects of leflunomide pretreatment in severe necrotizing pancreatitis in rats.