Leflunomide: is a new oral agent in treatment of acute pancreatitis?

Kutluana U., ORUÇ N. , NART D. , Kaptanoglu B., Yonetci N., OZUTEMIZ O.

Pancreas, vol.39, no.2, pp.237-42, 2010 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1097/mpa.0b013e3181bab6a9
  • Title of Journal : Pancreas
  • Page Numbers: pp.237-42


Objectives: Nuclear factor-kappa B (NF-kappa B) is a potent mediator in several steps of acute pancreatitis. Leflunomide is a novel immunomodulating drug that is also a potent inhibitor of NF-kappa B activation. The aim of this study was to investigate the effects of leflunomide pretreatment in severe necrotizing pancreatitis in rats.