The elevated markers of hypercoagulability in children with Henoch-Schonlein purpura


YILMAZ D., Kavakli K. , OZKAYIN N.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.22, no.1, pp.41-48, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1080/08880010590896251
  • Title of Journal : PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Page Numbers: pp.41-48
  • Keywords: child, Henoch-Schonlein purpura, hypercoagulability, VON-WILLEBRAND-FACTOR, FACTOR-XIII, COAGULATION, VASCULITIS

Abstract

Twenty-eight children with HSP and 79 healthy children were entered into study. Activities of protein C, free-protein S and antithrombin, activated protein C resistance, levels of fibrinogen. D-dimer, thrombin-antithrombin complex (TAT), prothrombin fragments 1 + 2 (PF1+2), and von Willrebrand factor antigen (vWAg) and its activity (RiCof) were investigated in acute and recovery phases of HSP and controls. Fibrinogen, D-dimer, TAT, PF1+2, vWAg, and RiCof levels in patients with HSP during the acute phase were significantly higher than those of recovery phase and of the controls. A significant correlation was detected between severity of disease and TAF, PF1+2, vWAg, and D-dimer levels.