The elevated markers of hypercoagulability in children with Henoch-Schonlein purpura

YILMAZ D., Kavakli K. , OZKAYIN N.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.22, ss.41-48, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 22 Konu: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/08880010590896251
  • Sayfa Sayıları: ss.41-48


Twenty-eight children with HSP and 79 healthy children were entered into study. Activities of protein C, free-protein S and antithrombin, activated protein C resistance, levels of fibrinogen. D-dimer, thrombin-antithrombin complex (TAT), prothrombin fragments 1 + 2 (PF1+2), and von Willrebrand factor antigen (vWAg) and its activity (RiCof) were investigated in acute and recovery phases of HSP and controls. Fibrinogen, D-dimer, TAT, PF1+2, vWAg, and RiCof levels in patients with HSP during the acute phase were significantly higher than those of recovery phase and of the controls. A significant correlation was detected between severity of disease and TAF, PF1+2, vWAg, and D-dimer levels.