Do salivary and serum collagenases have a role in an association between obstructive sleep apnea syndrome and periodontal disease? A preliminary case-control study


Nizam N. , Basoglu O. K. , Taşbakan M. , Holthofer A., Teruahartiala T., Sorsa T., ...More

ARCHIVES OF ORAL BIOLOGY, vol.60, pp.134-143, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60
  • Publication Date: 2015
  • Doi Number: 10.1016/j.archoralbio.2014.09.006
  • Title of Journal : ARCHIVES OF ORAL BIOLOGY
  • Page Numbers: pp.134-143
  • Keywords: Matrix metalloproteinases, Obstructive sleep apnea syndrome, Periodontal disease, Saliva, Serum, Tissue inhibitor of matrix, metalloproteinases-1, NECROSIS-FACTOR-ALPHA, MATRIX METALLOPROTEINASES, NEUTROPHIL ELASTASE, MYELOPEROXIDASE, PATHOGENESIS, INFLAMMATION, DOXYCYCLINE, POPULATION, ACTIVATION, DISORDERS

Abstract

Objectives: Despite increasing evidence for an association of obstructive sleep apnea syndrome (OSAS) and periodontal disease, the pathophysiological linking mechanisms remain unclear. This study aims to evaluate the salivary and serum matrix metalloproteinase-2, -8, -9 (MMP-2, -8, -9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), myeloperoxidase (MPO), neutrophil elastase (NE), neutrophil gelatinase-associated lipocalin (NGAL), as well as degree of activation of MMP-2, -9 of patients with and without OSAS.