Synthesis and characterization of folic acid-chitosan nanoparticles loaded with thymoquinone to target ovarian cancer cells


İNCE İ. , YILDIRIM Y. , Guler G., MEDİNE E. İ. , Ballica G., Kusdemir B. C. , ...Daha Fazla

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.324, ss.71-85, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 324 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s10967-020-07058-z
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.71-85

Özet

The aim of the present research was to formulate and characterize radioiodinated folic acid-chitosan conjugated thymoquinone nanoparticles (FATQCSNPs) and to increase targeting ability on ovarian cancer cell. The dose of drug-loading into the FATQCSNPs and the amount of folic acid on the FATQCSNPs surface were determined as a 20.0 +/- 1% and 46.0 +/- 0.5%, respectively. Cell viabilities (%) determined on SKOV-3 and Caco-2 cells for 48 h. TQ, TQCS and FATQCS were very cytotoxic with lower IC50 values on both cell lines. At specific-activity-dependent incorporation study, the incorporation efficiencies of I-131-FATQCSNPs was higher than that of I-131-TQ on SKOV3 cell lines.