Stiff Person syndrome- The less common antibody: a case report

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Özdemir H. N. , Yöndem D. , Kaplan S., Gökçay F.

Turkish Journal of Neurology, no.26, pp.39-41, 2020 (Journal Indexed in ESCI)

  • Publication Type: Article / Case Report
  • Publication Date: 2020
  • Title of Journal : Turkish Journal of Neurology
  • Page Numbers: pp.39-41


Stiff Person syndrome (SPS) is a rare, disabling syndrome characterized by progressive muscle stiffness and axial rigidity. It may have an autoimmune, paraneoplastic or cryptogenic etiology. A 59-year-old woman presented with stiffness and involuntary spasms in the lower extremities. In a neurologic examination, lower extremity and axial rigidity were revealed. Anti-glutamic acid decarboxylase antibody was negative, anti-amphiphysin was antibody positive. She was diagnosed as having SPS. The symptoms were improved after intravenous immunoglobulin and cancer therapy.