The effects of modified hemofiltration on inflammatory mediators and cardiac performance in coronary artery bypass grafting

BOGA M., Islamoglu F. , BADAK İ., CIKIRIKCIOGLU M., BAKALIM T., Yagdi T. , ...More

PERFUSION-UK, vol.15, no.2, pp.143-150, 2000 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1177/026765910001500209
  • Title of Journal : PERFUSION-UK
  • Page Numbers: pp.143-150


Cardiopulmonary bypass increases the blood levels of various immune mediators, thereby leading to a systemic inflammatory response syndrome, e.g. sepsis, with some hemodynamic alterations, such as vasodilatation, tachycardia, and a decrease in systemic vascular resistance. Perioperative hemofiltration is one of the treatment modalities proposed to prevent this syndrome. Modified hemofiltration has been introduced recently by investigators who recommend that the former standard techniques are ineffective in eliminating the inflammatory mediators. The purpose of this study was to determine the effects of the modified technique on these mediators and on hemodynamic parameters.