Synthesis and radical polymerizations of acrylamides having Gabapentin moieties


Akat H. , Balcan M.

E-POLYMERS, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Basım Tarihi: 2007
  • Dergi Adı: E-POLYMERS

Özet

The synthesis and radical polymerizations of several acrylamides having Gabapentin( GBP) moieties were examined. The monomers were prepared by the reactions of 1-aminomethyl-1-cyclohexane acetic acid salts with acryloyl chloride in the presence of triethylamine in moderate yields. Radical polymerizations of the monomers were carried out in the presence of AIBN ( 3 mol%) in Dimethyl formamide ( DMF) with moderate yield. The thermal behavior of the polymers was investigated by thermo gravimetric analysis ( TGA) and differential scanning calorimeter ( DSC) to determine the thermal degradation pattern and glass transition temperature ( T-g). The resulting polymers showed a thermal stability up to 400 degrees C. The glass transition temperatures of the polymers were found not to depend on the substituents of the GBP moieties. Nearly the same TG's were observed for polymers. We found the molecular weights of the polymers to be between 20700 and 2300 g/mol. We obtained poly( HFCHA) as a water-soluble polymer. Poly( MFCHA), poly( EFCHA) and poly( PFCHA) were soluble in common solvents.