In vitro evaluation of apoptosis with Tc-99m-glucoheptonate

Kocagozoglu G., Lambrecht F. , Gunduz C., Yucebas M., Tabar E. B. , Ozgur A., et al.

APPLIED RADIATION AND ISOTOPES, cilt.69, ss.955-959, 2011 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 69 Konu: 7
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.apradiso.2011.03.006
  • Sayfa Sayısı: ss.955-959


Radiopharmaceuticals are useful to evaluate effectiveness of cancer treatments as well as diagnosis of diseases. Tc-99m-Glucoheptonate has high sensitivity for imaging lung cancer tissues. In this study, the potential use of Tc-99m-glucoheptonate for monitoring apoptosis related to chemotherapeutic agents is investigated in vitro using A549 lung cancer cell line. A decrease in Tc-99m-glucoheptonate uptake ratio was observed depending on the level of apoptosis. Tc-99m-glucoheptonate is found to be useful for the detection of apoptosis following treatment in A549 lung tumor cells. (C) 2011 Elsevier Ltd. All rights reserved.