Aim. Intense physical activity is known to induce oxidative stress. Though regular physical training enhances the antioxidant defence system, the effects of diminished training periods are unclear. American football is one of the recently popular sports in Turkiye and is defined as a mixed activity. The aim of the research was to examine some markers of oxidative stress and antioxidant status in occasionally competitive American football players following a match, and relations with aerobic power and playing position.