Radiolabeling and in vitro evaluation of Tc-99m-methotrexate on breast cancer cell line


ÖZGENÇ E. , EKİNCİ M. , Ilem-Ozdemir D. , Gundogdu E., AŞIKOĞLU M.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.307, ss.627-633, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 307 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10967-015-4210-6
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.627-633

Özet

In the present study Tc-99m-MTX was prepared with high labeling yield by a new simple and easy formulation method. According to cell culture studies, Tc-99m-MTX incorporated with both MCF-7 and CRL8798 cells, with significant differences in the uptake percentages. Since Tc-99m-MTX highly uptake in cancer cell line, the results demonstrated that radiolabeled MTX may be promising for breast cancer diagnosis of oncological patients.