Diverse effects of calcium channel blockers in the collar model


Kerry Z. , YASA M. , SEVIN G. , REEL B. , ANACAK G. , OZER A.

ACTA CARDIOLOGICA, vol.60, no.5, pp.493-499, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.2143/ac.60.5.2004970
  • Title of Journal : ACTA CARDIOLOGICA
  • Page Numbers: pp.493-499

Abstract

Objective - Calcium channel blockers (CCBs) are among the most frequently prescribed cardiovascular drugs. It has been shown that these drugs have antiatherosclerotic effects in both experimental and clinical settings. However, calcium channel blockers have markedly different chemical structures and different effects on the cardiovascular system.We investigated the effect of CD-832, a Ca+2 channel antagonist, on collar-induced intimal thickening, as well as accompanied reactivity changes in rabbit carotid artery.