Taurine suppresses oxidative stress-potentiated expression of lectin-like oxidized low-density lipoprotein receptor and restenosis in balloon-injured rabbit iliac artery


GÖKÇE G. , OZSARLAK-SOZER G. , ORAN I. , Oktay G., Ozkal S., KERRY Z.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.38, no.12, pp.811-818, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 12
  • Publication Date: 2011
  • Doi Number: 10.1111/j.1440-1681.2011.05612.x
  • Title of Journal : CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Page Numbers: pp.811-818
  • Keywords: balloon injury, glutathione, lectin-like oxidized low-density lipoprotein receptor (LOX-1), restenosis, taurine, SMOOTH-MUSCLE CELLS, GLUTATHIONE DEPLETION, ANGIOTENSIN-II, ENDOTHELIAL DYSFUNCTION, NEOINTIMAL HYPERPLASIA, INTIMAL HYPERPLASIA, SCAVENGER RECEPTOR, RAT MODEL, LOX-1, ATHEROSCLEROSIS

Abstract

1. In endothelial cells, the major receptor for the binding and internalization of oxidized low-density lipoprotein (LDL) is the lectin-like oxidized LDL receptor (LOX-1). The aim of the present study was to investigate the effects of taurine on intimal thickening and LOX-1 expression under normal and oxidative conditions.